Role of molecular charge in glomerular permeability. Tracer studies with cationized ferritins.
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چکیده
منابع مشابه
Role of molecular charge in glomerular permeability. Tracer studies with cationized ferritins
Mouse kidneys were perfused with Krebs-Ringer bicarbonate buffer (KRB) containing native, anionic horse spleen ferritin or various cationized derivatives, and the glomerular localization of the probe molecules determined by electron microscopy. Ferritins cationic with respect to the medium (KRB, pH 7.45) accumulated in the subendothelial layers of the glomerular basement membrane (GBM) in amoun...
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The influence of molecular charge on glomerular permeability to the globular ferritin molecule in vivo was investigated. Mice (Charles River CD strain) and rats (Munich-Wistar strain) were injected intravenously either with native anionic ferritin or various cationized derivatives with different isoelectric points (pI) and the kidneys were examined by electron microscopy. Native anionic ferriti...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1975
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.67.3.638